Le aftosi ricorrenti sono condizione comune comprendente anche ulcere orali denominabili ‘simil-aftose’ (ALU), legate a malattie sistemiche e a carenze di ferro, acido folico e vitamina B12.
Trentadue adulti con aftosi ricorrente e 29 controlli sani sono stati sottoposti ad indagini ematologiche.
I pazienti con una storia negativa familiare hanno mostrato remissione completa degli episodi ulcerosi dopo terapia sostitutiva, mentre quelli con una storia familiare positiva avevano solo riduzione di frequenza e gravità.
La frequenza più elevata di ALU (rispetto alla variante idiopatica) associata con familiarità e la buona risposta alla terapia sostitutiva inducono a indagare sempre in tutti i pazienti con aftosi ricorrente, oltre la routine ematologica, eventuali carenze con test per sideremia, acido folico e vitamina B12.
J Eur Acad Dermatol Venereol. 2009 Nov 2. [Epub ahead of print]
Haematological deficiencies in patients with recurrent aphthosis.
Compilato D, Carroccio A, Calvino F, Di Fede G, Campisi G.
Abstract Background Recurrent aphthosis is a common oral ulcerative condition consisting also of a subset of similar ulcers, properly named ‘aphthous-like’ ulcers (ALU), linked to systemic diseases and among these, to iron, folic acid and vitamin B(12) deficiencies.
Objectives The main objectives of this study were: (i) to evaluate the association between recurrent aphthosis and the most common predisposing factors; (ii) to assess the frequency of ALU in recurrent aphthosis; (iii) to verify the efficacy of a replacement therapy in all ALU patients.
Methods Thirty-two adults with recurrent aphthosis and 29 otherwise healthy controls were consecutively recruited, interviewed and subjected to haematological investigations.
Results Family history of recurrent aphthosis was significantly associated (P < 0.01). The overall frequency of haematinic deficiencies was 56.2% in recurrent aphthosis patients vs. 7% in controls (P < 0.0001). All ALU patients with a negative family history showed a complete remission of the ulcerative episodes after replacement therapy, while those with a positive family history only had a reduction in frequency and severity. In the logistic regression model, only family history was associated with recurrent aphthosis (P = 0.0137).
Conclusion The strong association with familiarity, the unexpected higher frequency of ALU (compared with the idiopathic variant) and the good response to replacement therapy means that familiarity should always be investigated.
Furthermore, routine haematological screening and tests for serum iron, folic acid and vitamin B(12) deficiencies should be assessed in all patients with recurrent aphthosis to treat any nutritional deficiency and to prevent more important related systemic manifestations.
Filed under: AFTOSI | Tagged: AFTA, afta cura, afta cure, afta orale cure, afta orale rimedi, afta orale rimedio, afta orale terapia, afta orale trattamento, afta rimedi, afta rimedio, afta terapia, afta terapie, afta trattamenti, AFTE, afte cura, ALLERGIA, ALLERGIA ALIMENTARE, dermatologo, Prof. Santoianni |