Studio con la risonanza magnetica funzionale (fMRI) del processo cerebrale del prurito istamina-indotto in pazienti con dermatite atopica rispetto a soggetti sani di controllo.
Viene dimostrato che la fMRI è una tecnica promettente per valutare l’attività del cervello nel prurito cronico.
L’attività cerebrale nel prurito acuto nella dermatite atopica sembra differire da quella in soggetti sani. Inoltre, l’attività in aree corticali coinvolte nell’ affetto ed emozione correlano con la gravità della malattia.
Br J Dermatol. 2009 Nov;161(5):1072-80. Epub 2009 May 15.
Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis.
Ishiuji Y, Coghill RC, Patel TS, Oshiro Y, Kraft RA, Yosipovitch G.
To examine the difference in brain processing of histamine-induced itch in patients with active atopic dermatitis (AD) vs. healthy controls with the emerging technique of functional magnetic resonance imaging (fMRI) using arterial spin labelling (ASL).
Itch was induced with histamine iontophoresis in eight patients with AD and seven healthy subjects. RESULTS: We found significant differences in brain processing of histamine-induced itch between patients with AD and healthy subjects. Patients with AD exhibited bilateral activation of the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), retrosplenial cingulate cortex and dorsolateral prefrontal cortex (DLPFC) as well as contralateral activation of the caudate nucleus and putamen. In contrast, healthy subjects activated the primary motor cortex, primary somatosensory cortex and superior parietal lobe. The PCC and precuneus exhibited significantly greater activity in patients vs. healthy subjects. A significant correlation between percentage changes of brain activation was noted in the activation of the ACC and contralateral insula and histamine-induced itch intensity as well as disease severity in patients with AD. In addition, an association was noted between DLPFC activity and disease severity.
CONCLUSIONS: Our results demonstrate that ASL fMRI is a promising technique to assess brain activity in chronic itch. Brain activity of acute itch in AD seems to differ from that in healthy subjects. Moreover, the activity in cortical areas involved in affect and emotion correlated to measures of disease severity.
Filed under: DERMATITE ATOPICA, PRURITO | Tagged: causa del prurito, causa dematite atopica, cura del prurito, cura dermatite atopica, cura eczema, DERMATITE ATOPICA, DERMATITE ATOPICA BAMBINI, dermatologo, ECZEMA, Prof. Santoianni, PRURITO, terapia del prurito, terapia dermatite atopica, terapia eczema |