Aftosi:trattamenti

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Il trattamento della stomatite aftosa ricorrente resta ancora non specifico e si basa principalmente su dati empirici. Gli obiettivi della terapia sono la gestione del dolore e della compromissione funzionale sopprimendo la infiammazione, nonché ridurre la frequenza delle recidive o di evitare l’insorgenza di nuove afte.

Per le forme comuni opzioni standard di trattamento topico che forniscono sollievo sintomatico comprendono analgesici, anestetici, antisettici, agenti anti-infiammatori, steroidi, sucralfato, tetraciclina locale.

Nei casi resistenti o con coinvolgimento sistemico un adeguato trattamento sistemico può essere selezionato da un ampio spettro di immunomodulatori.

Skin Therapy Lett. 2008 Sep;13(7):1-4.

Current concepts in the treatment of recurrent aphthous stomatitis.

Altenburg A, Zouboulis CC.

The treatment of recurrent aphthous stomatitis (RAS) still remains nonspecific and is based primarily on empirical data. The goals of therapy include the management of pain and functional impairment by suppressing inflammatory responses, as well as reducing the frequency of recurrences or avoiding the onset of new aphthae.

For common forms of RAS, standard topical treatment options that provide symptomatic relief include analgesics, anesthetics, antiseptics, anti-inflammatory agents, steroids, sucralfate, tetracycline suspension, and silver nitrate.

Dietary modifications may also support therapeutic measures.

In resistant cases of benign aphthosis or aphthosis with systemic involvement, appropriate systemic treatment can be selected from a wide spectrum of immunomodulators that include colchicine, prednisolone, cyclosporine A, interferon-a, tumor necrosis factor-a antagonists, antimetabolites, and alkylating agents.

Diete di eliminazione nella dermatite atopica

Dietary exclusions for established atopic eczema

Cochrane Database of Systematic Reviews, Issue 4, 2009

Bath-Hextall FJ, Delamere FM, Williams HC.

Objectives
To assess the effects of dietary exclusions for the treatment of established atopic eczema.
Search strategy
We searched The Cochrane Skin Group Specialised Register (to March 2006), The Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (Issue 1, 2006), MEDLINE (2003 to March 2006), EMBASE (2003 to March 2006), LILACS (to March 2006), PsycINFO (1806 to March 2006), AMED (1985 to March 2006), ISI Web of Science (March 2006), http://www.controlled-trials.com, http://www.clinicaltrials.gov and http://www.nottingham.ac.uk/ongoingskintrials (March 2006). Pharmaceutical companies were contacted where appropriate for reviews or unpublished trials.
Data collection and analysis
Two independent authors carried out study selection and assessment of methodological quality.
Main results
We found 9 RCTs involving a total of 421 participants of which 6 were studies of egg and milk exclusion (N=288), 1 was a study of few foods (N=85) and 2 were studies of an elemental diet (N=48).

There appears to be no benefit of an egg and milk free diet in unselected participants with atopic eczema. There is also no evidence of benefit in the use of an elemental or few-foods diet in unselected cases of atopic eczema.
There may be some benefit in using an egg-free diet in infants with suspected egg allergy who have positive specific IgE to eggs – one study found 51% of the children had a significant improvement in body surface area with the exclusion diet compared to normal diet (RR 1.51, 95% CI 1.07 to 2.11) and change in surface area and severity score was significantly improved in the exclusion diet compared to the normal diet at the end of 6 weeks (MD 5.50, 95% CI 0.19 to 10.81) and end of treatment (MD 6.10, 95% CI 0.06 to12.14).

Methodological difficulties have made it difficult to interpret these studies. Poor concealment of randomisation allocation, lack of blinding and high dropout rates without an intention-to-treat analysis indicates that these studies should be interpreted with great caution.
Conclusions
There may be some benefit in using an egg-free diet in infants with suspected egg allergy who have positive specific IgE to eggs.
Little evidence supports the use of various exclusion diets in unselected people with atopic eczema, but that may be because they were not allergic to those substances in the first place. Lack of any benefit may also be because the studies were too small and poorly reported.
Future studies should be appropriately powered focusing on participants with a proven food allergy. In addition a distinction should be made between young children whose food allergies improve with time and older children/adults.

Dietary exclusions for improving established atopic eczema in adults and children
Atopic eczema is the most common inflammatory skin disease of childhood in developed countries. The cause of atopic eczema is probably due to a combination of genetic and environmental factors.
Atopic eczema varies in severity, often from one hour to the next and the disease can be associated with complications such as bacterial and viral infections. There is a substantial economic cost not only to the family of the person with atopic eczema but also to health services.
Although there is currently no cure for atopic eczema, a wide range of treatments are used to control the symptoms. One such approach is a dietary one, whereby certain foods such as cows’ milk are excluded on the basis that they are thought to cause eczema to worsen. The reason for undertaking this review is because the effectiveness of removing various foods from the diet in the short term management of atopic eczema is unclear.

The general quality of the studies was poor. The main findings of the review suggest that there is some evidence from one study for the use of an egg-free diet in infants with a suspected egg allergy who have positive specific IgE antibodies to eggs in their blood.

Other studies that compared a dietary exclusion with ordinary diets did not test the people taking part to see if they were allergic to the foods concerned.
There appears to be little benefit in eliminating cows milk from the diet or using an elemental (liquid diet containing only amino acids, carbohydrates, fat, minerals and vitamins) or ‘few foods diet’ for improving atopic eczema in people who have not undergone any form of testing.

Three of the studies used soya based substitute which itself can be allergenic to people with atopic eczema.

Adhering to elimination diets is difficult. The studies were performed in different populations with only one study describing the severity of the atopic eczema. The clinical relevance of changes in severity scores obtained in many studies is unknown.

Antistaminici e malattie allergiche in bambini

Evaluation of treatment satisfaction in children with allergic disease treated with an antihistamine: an international, non-interventional, retrospective study.

Ferrer M, Morais-Almeida M, Guizova M, Khanferyan R.

Clin Drug Investig. 2010;30(1):15-34.